If anyone finds this thread because they or someone in their life is currently facing down a pancreatic cancer diagnosis I want you to know that we had significant success with our loved one by focusing, on our end, on diet.
The patient's metastasis markers were so high the value was literally off of the maximum value on the graph on the chart they gave us in the literature, and so, well beyond the level of being surgery eligible.
Over the 12 chemo cycles that number dropped to levels that cancer free people have, and they have gone on to outlive almost every statistic and remain cancer free to this day.
When researching pancreatic cancer following their diagnosis one thing that stood out to me is how the majority of scientific knowledge surrounding cancer addresses the cancer's metabolism. Pancreatic cancer is an IGF-1 (Insulin Growth Factor) metabolic cancer. This can be interpreted as the cancer uses sugar as its fuel source to grow, and in the absence of sugar can alter its internal metabolism to use an amino acid called glutamine as fuel instead. Glutamine is an amino acid found in animal products such as meat and dairy.
With this knowledge we went with a food regiment of removing ALL sugar, and animal products.
The results were significant. Even in their 70s they were able to do the full 12 cycle chemo treatment without needing to delay a single cycle due to negative health markers, and without any major side effects (except fatigue).
The tumor shrunk form 4.2 cm to 2 cm after 6 chemo treatments, and finally shrunk to 1 cm following their final treatment before surgery. (Compare this to studies on tumor shrinkage for the same cancer and chemo treatment, such as: https://www.healio.com/news/gastroenterology/20210722/early-... )
It is my opinion that at this time medical treatment is essential, both chemo and surgical intervention, but if you want something that you can do to try to increase the efficacy of those treatments I highly recommend this nutritional vector as well!
What are people doing at home? I have like 5 different apps I code on the $20/month Claude plan and like sure I can hit rate limits but - What are people doing to burn through $3k in tokens?
Mandatory voting is worthy of praise, some of the stuff you mentioned proves my point. Aboriginals are now part of that mandatory voting and as such the government bends over backwards to try and meet their needs while balancing them with the needs of others.
You are moving the goalposts, you asked to name a good government and I gave you one. On a spectrum from good to bad Australia is good.
If you ask to see a good horse and I show you one that can run at 30kmph, you can't in good faith complain that it requires oxygen and sometimes poops. It's not a bad horse because it can't fly.
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I think this is only going to become more relevant. I'm personally a $200/mo Claude Maxer and I know that the usage I'm getting on Opus 4.8 Max and (until they yoked it out from under me) Fable 5 is way, way more than what I'm paying them. At some point, this will turn usage-based and I will be hammered on it and probably forced to look at self-hosting. I think while the caps are there, even at $200, it's honestly not too bad if you're coding value into the market, but as soon as those caps come off for retail AI users, we're all going to have some tough choices to make.
Transmit and receive mechanical-television-style video through audio over a cable, WAV file, or pure software loopback. Classic 32-line club NBTV, and experimental wideband modes up to 480 lines that turn a 24-bit/192 kHz sound card into a surprisingly capable video link. It can even send files over the video channel as a stream of QR frames. In Python.
Luckily the future is absolutely going to be that star trek one where technological abundance means we are all wealthy and have free time to develop personally, and not the future where all the money bubbles up into the hands of a thin-skinned malignant narcissist who wants to play with launching rockets and provoking racial violence /s
Luckily I needed a new laptop and I bought an M1 Max secondhand from a friend quite cheaply because it was fast enough to recompile something else I am interested in.
So for me, there is no additional hardware cost; it was acquired in replacement.
I run the AI models at home on this kit because I want to; I'll use openrouter if I need to.
I accept the economics of this article are right. But I feel so incredibly sad about this outcome that we're now just to be people caretaking machines that do the job we loved that actually I am not sure that exercising this nuance is going to matter in the long term.
It turns out it is a mistake I have made in my life — now really unfixable because I am a bit too old — to believe that I will always find enough fulfilment in my work to offset the absence of personal fulfilment elsewhere; I have always enjoyed being able to help people directly by doing a thing I love and I am good at, and that has kept away the sadness of finding it difficult to build a conventional family life to enjoy.
I assumed I would always find some new way to find that enjoyment, but even the slim enjoyment from being able to explore this stuff on my own kit in my own terms will not be enough if the pendulum does not swing back towards human effort.
It is a dismal world we have made for ourselves. Lately I have found myself dreading growing too much older in it.
FFmpeg is extremely complex software, with an extreme (and necessary) focus on performance, that exists in an extremely complex domain.
It’s not just FFmpeg. Apple has had more vulnerabilities in image and video decoders than I can count. That stuff is just very hard, and FFmpeg is doing more than anyone else.
I've been thinking a lot about this and my personal take right now is that at some near-medium future the models abvailable to run at home and the hardware needed to use them will be enough.
My baseline is sonnet 4.6. I think it's good enough for most tasks sincerly. So, from what I see, we are already at a point where we don't need frontier models for serious coding and debuging. Give it a couple of years and that level will fit 120B models.
At the same time, we saw the rise of direct acess memory systems like DGX or Stryx Halo that will allow to run models of this size for "cheap" in the medium term.
That's what I'm betting in. That in 2 years I can buy a system for about $2500 that will run a model that's similar to Sonnet 4.6 locally.
I might be spectacularly wrong though. But I'm willing to wait and use subscriptions/API calls for now.
Right, but the widespread literacy took generations to take hold. But, the threat was immediate.
I think, in the long run, of course AI is a boon. But I’m not immortal, and right now it’s a threat to all our livelihoods. We should put ourselves first, and be selfish, while we’re still alive to be selfish.
Positive examples are all other animations that do work well, or are just animated in After Effects, for which there are plenty of examples online already, like on Twitter.
If an identical task takes a day on both sides, then the human route uses less energy, surely.
Brains are thousands or maybe even millions of times more fuel-efficient than computers and you are alive for the whole day either way, right? You probably eat about the same even.
The reason executives think AI is more efficient is that it more space efficient than a human and doesn't demand to be paid or work only a set number of hours. Everything with computing is more efficient if you resent having to give money to other humans. If they could just not have you be alive when they don't need you, it'd possibly be different.
Even though I think at a typical British freelance rate and a truly unsubsidised token price, the AI is possibly more expensive than me. And as a freelancer, from their perspective I really am not alive until they need me. (This is what it often feels like)
The reality is the human and the AI aren't used to build the same things anyway so it's a comparison you can't really make.
Gh issues works surprisingly well as an agent board. Labels for state, one issue per feature. The part i haven't figured out yet is how to know when the output is actually done vs just "looks done" to the agent.
The patient's metastasis markers were so high the value was literally off of the maximum value on the graph on the chart they gave us in the literature, and so, well beyond the level of being surgery eligible.
Over the 12 chemo cycles that number dropped to levels that cancer free people have, and they have gone on to outlive almost every statistic and remain cancer free to this day.
When researching pancreatic cancer following their diagnosis one thing that stood out to me is how the majority of scientific knowledge surrounding cancer addresses the cancer's metabolism. Pancreatic cancer is an IGF-1 (Insulin Growth Factor) metabolic cancer. This can be interpreted as the cancer uses sugar as its fuel source to grow, and in the absence of sugar can alter its internal metabolism to use an amino acid called glutamine as fuel instead. Glutamine is an amino acid found in animal products such as meat and dairy.
With this knowledge we went with a food regiment of removing ALL sugar, and animal products.
The results were significant. Even in their 70s they were able to do the full 12 cycle chemo treatment without needing to delay a single cycle due to negative health markers, and without any major side effects (except fatigue).
The tumor shrunk form 4.2 cm to 2 cm after 6 chemo treatments, and finally shrunk to 1 cm following their final treatment before surgery. (Compare this to studies on tumor shrinkage for the same cancer and chemo treatment, such as: https://www.healio.com/news/gastroenterology/20210722/early-... )
It is my opinion that at this time medical treatment is essential, both chemo and surgical intervention, but if you want something that you can do to try to increase the efficacy of those treatments I highly recommend this nutritional vector as well!
Best wishes for you and your loved ones.